Co-Delivery Using pH-Sensitive Liposomes to Pancreatic Cancer Cells: the Effects of Curcumin on Cellular Concentration and Pharmacokinetics of Gemcitabine.

Hongtao XuYan LiJames W PaxtonZimei Wu

Published in: Pharmaceutical research (2021)

Co-delivery of curcumin with gemcitabine using PSL not only increased the intracellular gemcitabine concentration thus cytotoxicity to MIA PaCa-2 cells but also significantly improved the pharmacokinetic profiles for both drugs. Graphical Abstract.

Keyphrases

locally advanced
induced apoptosis
drug delivery
squamous cell carcinoma
reactive oxygen species