Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models.
Esther ParadaAna I CasasAlejandra Palomino-AntolinVanessa Gómez-RangelAlfonso Rubio-NavarroVictor Farré-AlinsPaloma Narros-FernandezMelania Guerrero-HueJuan Antonio MorenoJuliana M RosaJosé M RodaBorja J Hernández-GarcíaJavier EgeaPublished in: British journal of pharmacology (2019)
TLR4 signalling has a causal role in the inflammation associated with a poor post-stroke outcome. Importantly, its inhibition by eritoran (E5564) provides neuroprotection both in vitro and in vivo, including in human tissue, suggesting a promising new therapeutic approach for ischaemic stroke.