Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow via brain inducible NO synthase-mediated S-nitrosylation.

Youichirou HigashiTakahiro ShimizuMasaki YamamotoKenjiro TanakaToshio YawataShogo ShimizuSuo ZouTetsuya UebaKazunari YuriMotoaki Saito

Published in: British journal of pharmacology (2018)

Stimulation of brain nAChRs can induce elevation of plasma catecholamines through brain iNOS-derived NO-mediated protein S-nitrosylation in rats. Therefore, brain nAChRs (at least α4β2 subtype) and NO might be useful targets for alleviation of catecholamines overflow induced by smoking.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
multiple sclerosis
small molecule
brain injury
amino acid