Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa.
K Varsha MohanAlaknanda MishraAbaranjitha MuniyasamyPrakriti SinhaParul SahuAshwani KesarwaniKshama JainPerumal NagarajanVinod ScariaManisha AgarwalNaseem S AkhterChanda GuptaPramod UpadhyayPublished in: Orphanet journal of rare diseases (2022)
Our studies with RP patients and rd1 mouse model suggest that immunological consequences in RP is a contributing factor in the progression of retinal degeneration. The ocular inflammation in the RP alters the ocular immune privilege mechanisms and peripheral immune response. These aberrations in turn create an auto-reactive immune environment and accelerate retinal degeneration.
Keyphrases
- optic nerve
- optical coherence tomography
- diabetic retinopathy
- immune response
- mouse model
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- oxidative stress
- peritoneal dialysis
- prognostic factors
- toll like receptor
- patient reported outcomes
- copy number
- dendritic cells
- dna methylation
- sensitive detection
- fluorescent probe
- single molecule