Optical Resolution of Rimantadine.

Jianlin HanRyosuke TakedaTatsunori SatoHiroki MoriwakiHidenori AbeKunisuke IzawaVadim A Soloshonok

Published in: Molecules (Basel, Switzerland) (2019)

This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies.

Keyphrases

low cost
single molecule
high resolution
minimally invasive
high speed