Nanoclay Drug-Delivery System Loading Potassium Iodide Promotes Endocytosis and Targeted Therapy in Anaplastic Thyroid Cancer.
Peng HuangNeng TangLin-Feng MaoYi ZhangXiao-Feng TangRuo-Yun ZhouBo WeiHai-Long TanQi-Man ShiJing LinZhe-Cheng LiShi ChangPublished in: Nano letters (2023)
The rapid proliferative biological behavior of primary foci of anaplastic thyroid cancer (ATC) makes it a lethal tumor. According to the specific iodine uptake capacity of thyroid cells and enhanced endocytosis of ATC cells, we designed a kind of nanoclay drug-loading system and showed a promising treatment strategy for ATC. Introducing potassium iodide (KI) improves the homoaggregation of clay nanoparticles and then affects the distribution of nanoparticles in vivo, which makes KI@DOX-Kaolin MeOH enriched almost exclusively in thyroid tissue. Simultaneously, the improvement of dispersibility of KI@DOX-Kaolin MeOH changes the target uptake of ATC cells by improving the endocytosis and nanoparticle-induced autophagy, which regulate the production of autolysosomes and autophagy-enhanced chemotherapy, eventually contributing to a tumor inhibition rate of more than 90% in the primary foci of ATC. Therefore, this facile strategy to improve the homoaggregation of nanoclay by introducing KI has the potential to become an advanced drug delivery vehicle in ATC treatment.
Keyphrases
- induced apoptosis
- cell cycle arrest
- endoplasmic reticulum stress
- cell death
- drug delivery
- signaling pathway
- neoadjuvant chemotherapy
- oxidative stress
- emergency department
- magnetic resonance
- radiation therapy
- high glucose
- smoking cessation
- rectal cancer
- locally advanced
- pi k akt
- sensitive detection
- adverse drug
- quantum dots
- human health