Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.

Luwei HeHuaguang LiChenyu PanYutong HuaJiayin PengZhaocai ZhouYun ZhaoMoubin Lin

Published in: Cancer communications (London, England) (2021)

Our findings demonstrate that SQLE promotes CRC through the accumulation of calcitriol and stimulation of CYP24A1-mediated MAPK signaling, highlighting SQLE as a potential therapeutic target for CRC treatment.

Keyphrases

signaling pathway
cell proliferation
pi k akt
oxidative stress
cell cycle
replacement therapy