TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer.

Karen SlatteryElena WoodsVanessa Zaiatz-BittencourtSam MarksSonya ChewMichael ConroyCaitriona GogginColm MacEochagainJohn KennedySophie LucasDavid K FinlayClair M Gardiner

Published in: Journal for immunotherapy of cancer (2022)

TGFβ contributes to metabolic dysfunction of circulating NK cells in patients with metastatic breast cancer. Blocking TGFβ and/or GARP can restore NK cell metabolism and function and is an important target for improving NK cell-based immunotherapies.

Keyphrases

nk cells
metastatic breast cancer
transforming growth factor
endothelial cells
oxidative stress
epithelial mesenchymal transition
signaling pathway