Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study.
Emma A HurstRichard J MellanbyIan HandelDavid M GriffithAdriano G RossiTimothy S WalshManu Shankar-HariJake DunningNatalie Z HomerScott G DenhamKerri DevinePaul A HollowayShona C MooreRyan S ThwaitesRomit J SamantaCharlotte SummersHayley E HardwickWilna OosthuyzenLance TurtleMalcolm G SemplePeter J M OpenshawJ Kenneth BaillieClark D Russellnull nullPublished in: BMJ open (2021)
Vitamin D deficiency/insufficiency was present in majority of hospitalised patients with COVID-19 or influenza A and correlated with severity and persisted in critical illness survivors at concentrations expected to disrupt bone metabolism. These findings support early supplementation trials to determine if insufficiency is causal in progression to severe disease, and investigation of longer-term bone health outcomes.