Activated HLA-DR+CD38+ Effector Th1/17 Cells Distinguish Crohn's Disease-associated Perianal Fistulas from Cryptoglandular Fistulas.

Laura F OuboterCiska LindelaufQinyue JiangMette SchreursTamim R AbdelaalSietse J LukMarieke C BarnhoornWillem E HuetingIngrid J Han-GeurtsKoen C M J PeetersFabian A HolmanFrits KoningAndrea E van der Meulen-de JongMaria Fernanda Pascutti

Published in: Inflammatory bowel diseases (2024)

Overall, proliferating activated HLA-DR+CD38+ effector Th1/17 cells distinguish CD-associated from cryptoglandular perianal fistulas and are a promising biomarker in blood to discriminate between these 2 fistula types. Targeting HLA-DR and CD38-expressing CD4+ T cells may offer a potential new therapeutic strategy for CD-related fistulas.

Keyphrases

induced apoptosis
nk cells
cell cycle arrest
regulatory t cells
dendritic cells
risk assessment
oxidative stress
signaling pathway
pi k akt