Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis.
Yuki MakinoHayato HikitaKenji FukumotoJi Hyun SungYoshihiro SakanoKazuhiro MuraiSadatsugu SakaneTakahiro KodamaRyotaro SakamoriJumpei KondoShogo KobayashiTomohide TatsumiTetsuo TakeharaPublished in: Cancer research (2022)
This study reveals that activation of p53 in hepatocytes promotes liver carcinogenesis derived from HPCs, which elucidates a paradoxical aspect of a tumor suppressor p53 and novel mechanism of liver carcinogenesis. See related commentary by Barton and Lozano, p. 2824.