Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells.
Ann-Ki PålbrinkFranziska KopietzBjörn MorénRené In 't ZandtFederico KalinecKarin StenkulaOlga GöranssonCecilia HolmMåns MagnussonEva DegermanPublished in: BMJ open diabetes research & care (2021)
The organ of Corti could be a target tissue for insulin action, and inner ear insulin resistance might contribute to the association between diabetes and inner ear dysfunction.
Keyphrases
- type diabetes
- insulin resistance
- glycemic control
- high fat diet induced
- induced apoptosis
- high fat diet
- adipose tissue
- metabolic syndrome
- polycystic ovary syndrome
- skeletal muscle
- cardiovascular disease
- cell cycle arrest
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- cell proliferation
- hearing loss
- wild type