Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes.
Cetewayo S RashidAmita BansalRebecca A SimmonsPublished in: Physiology (Bethesda, Md.) (2019)
Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.
Keyphrases
- oxidative stress
- type diabetes
- birth weight
- skeletal muscle
- glycemic control
- dna damage
- diabetic rats
- insulin resistance
- ischemia reperfusion injury
- cardiovascular disease
- induced apoptosis
- gene expression
- cell death
- weight gain
- depressive symptoms
- physical activity
- adipose tissue
- metabolic syndrome
- reactive oxygen species
- body mass index
- endoplasmic reticulum
- weight loss