Pleiotropic Roles of Atrial Natriuretic Peptide in Anti-Inflammation and Anti-Cancer Activity.
Hua-Feng FuJian ZhangQinbo CaiYulong HeDongjie YangPublished in: Cancers (2022)
The atrial natriuretic peptide (ANP), a cardiovascular hormone, plays a pivotal role in the homeostatic control of blood pressure, electrolytes, and water balance and is approved to treat congestive heart failure. In addition, there is a growing realization that ANPs might be related to immune response and tumor growth. The anti-inflammatory and immune-modulatory effects of ANPs in the tissue microenvironment are mediated through autocrine or paracrine mechanisms, which further suppress tumorigenesis. In cancers, ANPs show anti-proliferative effects through several molecular pathways. Furthermore, ANPs attenuate the side effects of cancer therapy. Therefore, ANPs act on several hallmarks of cancer, such as inflammation, angiogenesis, sustained tumor growth, and metastasis. In this review, we summarized the contributions of ANPs in diverse aspects of the immune system and the molecular mechanisms underlying the anti-cancer effects of ANPs.
Keyphrases
- heart failure
- blood pressure
- immune response
- cancer therapy
- oxidative stress
- atrial fibrillation
- anti inflammatory
- stem cells
- drug delivery
- squamous cell carcinoma
- type diabetes
- ionic liquid
- metabolic syndrome
- heart rate
- vascular endothelial growth factor
- single molecule
- catheter ablation
- inflammatory response
- insulin resistance
- wound healing