Dietary cinnamaldehyde activation of TRPA1 antagonizes high-salt induced hypertension through restoring renal tubular mitochondrial dysfunction.

The present study demonstrated that chronic activation of Trpa1 attenuates HS-induced hypertension by inhibiting urinary sodium reabsorption through restoring renal tubular epithelial mitochondrial function. Renal TRPA1 may be a potential target for the management of excessive dietary salt intake-associated hypertension.