Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan.
Cesheng LiDing YuXiao WuHong LiangZhijun ZhouYong XieTaojing LiJunzheng WuFengping LuLu FengMin MaoLianzhen LinHuanhuan GuoShenglan YueFeifei WangYan PengYong HuZejun WangJianhong YuYong ZhangJia LuHaoran NingHuichuan YangDaoxing FuYanlin HeDongbo ZhouTao DuKai DuanDemei DongKun DengXia ZouYa ZhangRong ZhouYang GaoXinxin ZhangXiao Ming YangPublished in: Nature communications (2021)
To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- immune response
- binding protein
- newly diagnosed
- kidney transplantation
- oxidative stress
- prognostic factors
- bone marrow
- ejection fraction
- mesenchymal stem cells
- transcription factor
- endothelial cells
- toll like receptor
- small molecule
- high glucose
- protein protein