Diagnostic performance of the GenoType MTBDRplus VER 2.0 line probe assay for the detection of isoniazid resistant Mycobacterium tuberculosis in Ethiopia.

Shewki MogaKidist BoboshaDinka FikaduBetselot Zerihun Getu DiribaMisikir AmareRussell R KempkerHenry M BlumbergTamrat Abebe

Published in: PloS one (2023)

GenoType MTBDRplus VER 2.0 LPA demonstrated improved performance in detecting INH resistance among MDR-TB cases compared to Hr-TB cases. The katG315 mutation is the most common INH resistance conferring gene among Hr-TB and MDR-TB isolates. Additional INH resistance conferring mutations should be evaluated to improve the sensitivity of the GenoType MTBDRplus VER 2.0 for the detection of INH resistance among Hr-TB cases.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
multidrug resistant
gene expression
transcription factor
single cell
high throughput
label free