Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides.

Shu-Ting HongHuaching LinChen-Shen WangChih-Hsien ChangAnya Maan-Yuh LinJames Chih-Hsin YangYu-Li Lo

Published in: Journal of nanobiotechnology (2019)

This study proposes a multifunctional nanoparticle formulation for targeted modulation of apoptosis/EGFR/HER/EMT/resistance/progression pathways to increase the sensitivity of colon cancer cells to afatinib.

Keyphrases

cancer therapy
drug delivery
epidermal growth factor receptor
small cell lung cancer
oxidative stress
advanced non small cell lung cancer
epithelial mesenchymal transition
tyrosine kinase
endoplasmic reticulum stress
cell death
photodynamic therapy
cell cycle arrest
drug release
amino acid
signaling pathway