Copper-mediated DNA damage caused by purpurin, a natural anthraquinone.
Hatasu KobayashiYurie MoriRyo IwasaYuichiro HiraoShinya KatoShosuke KawanishiMariko MurataShinji OikawaPublished in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2022)
We demonstrated that purpurin induces DNA base damage possibly mediated by Cu(I)/Cu(II) redox cycle both with and without ROS generation, which are likely to play an important role in its carcinogenicity.