Diabetogenic effect of pravastatin is associated with insulin resistance and myotoxicity in hypercholesterolemic mice.
Estela Lorza-GilMarta García-ArevaloBianca Cristine FaveroMaria Cristina C Gomes-MarcondesHelena C F OliveiraPublished in: Journal of translational medicine (2019)
In addition to reduced insulin secretion, long-term pravastatin treatment induces insulin resistance and muscle wasting. These results suggest that the diabetogenic effect of statins is linked to the appearance of myotoxicity induced by oxidative stress, impaired insulin signalling, proteolysis and apoptosis.
Keyphrases
- insulin resistance
- oxidative stress
- high fat diet induced
- type diabetes
- skeletal muscle
- adipose tissue
- metabolic syndrome
- high fat diet
- polycystic ovary syndrome
- glycemic control
- cardiovascular disease
- dna damage
- cell cycle arrest
- ischemia reperfusion injury
- cell death
- induced apoptosis
- diabetic rats
- cell proliferation
- replacement therapy
- weight loss