Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.

Wenbiao WangDingwen HuYuqian FengCaifeng WuYunting SongWeiyong LiuAixin LiYingchong WangKeli ChenMingfu TianFeng XiaoQi ZhangWeijie ChenPan PanPin WanYingle LiuHuiyao LanKailang WuJian-Guo Wu

Published in: BMC biology (2020)

We have identified paxillin as a mediator of NLRP3 inflammasome activation. Paxillin plays key roles in ATP-induced activation of the P2X7 receptor and NLRP3 inflammasome by facilitating the formation of the P2X7R-Paxillin-NLRP3 complex.

Keyphrases

nlrp inflammasome
high glucose
diabetic rats
drug induced
endothelial cells
oxidative stress