HLA-DRB1 and cytokine polymorphisms in Brazilian patients with myelodysplastic syndromes and its association with red blood cell alloimmunization.

Marilia Fernandes Mascarenhas SirianniEmilia SippertBruna BlosFlavia Ricioli Vaz GonçalvesNelson HamerschlakJose KutnerLilian CastilhoLuciana Carvalheiro MartiCarolina Bonet Bub

Published in: Transfusion medicine (Oxford, England) (2022)

This study showed no association regarding HLA-DRB1 alleles for RBC alloimmunization risk or protection, however the IL17A 197G>A, IL4 intron 3 and IL4 590C>T SNP was significantly associated to RBC alloimmunization risk in this cohort of Brazilian MDS patients.

Keyphrases

red blood cell
end stage renal disease
sickle cell disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
genome wide
patient reported