Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis.

Minori SasakuraHitoshi UrakamiKota TachibanaKenta IkedaKen-Ichi HasuiYoshihiro MatsudaKo SunagawaDaisuke EnnishiShuta TomidaShin Morizane

Published in: Allergology international : official journal of the Japanese Society of Allergology (2024)

Topical T-5224 ameliorates clinical manifestations of AD-like dermatitis in mice. The effect of this inhibitor is amplified via combined use with JAK inhibitors.

Keyphrases

atopic dermatitis
wound healing
oxidative stress
signaling pathway
high fat diet induced
mouse model
metabolic syndrome
binding protein
small molecule
toll like receptor
inflammatory response