Precise targeting of miR-141/200c cluster in chondrocytes attenuates osteoarthritis development.

Ming-Liang JiHua JiangFei WuRui GengLi Kun YaYu Cheng LinJi Hao XuXiao Tao WuJun Lu

Published in: Annals of the rheumatic diseases (2020)

Our findings indicate that this nanocarrier can optimise the transport kinetics of miR-141/200c into chondrocytes, fostering miRNA-specific disease-modifying OA drugs development.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
knee osteoarthritis
drug delivery
rheumatoid arthritis
extracellular matrix
cancer therapy