A bioinspired silica nanocomposite for enhanced multidrug-resistant bacteria treatment and wash-free imaging.
Xiaokun LiuZhiying ZhangNikodem TomczakCong YangChengjun LiRongrong LiuBing YanPublished in: Nanoscale advances (2023)
Bacterial infections have posed significant threats to public health due to the emergence of antibiotic resistance. In this work, a novel antibacterial composite nanomaterial based on spiky mesoporous silica spheres loaded with poly(ionic liquid)s and aggregation-induced emission luminogens (AIEgens) was designed for efficient multidrug-resistant (MDR) bacteria treatment and imaging. The nanocomposite exhibited excellent and long-term antibacterial activity towards both Gram-negative and Gram-positive bacteria. Meanwhile, fluorescent AIEgens facilitate real-time bacterial imaging. Our study provides a multifunctional platform and a promising alternative to antibiotics for combating pathogenic MDR bacteria.
Keyphrases
- multidrug resistant
- gram negative
- drug resistant
- acinetobacter baumannii
- public health
- high resolution
- ionic liquid
- klebsiella pneumoniae
- drug delivery
- quantum dots
- high throughput
- cancer therapy
- escherichia coli
- cystic fibrosis
- mass spectrometry
- carbon nanotubes
- anti inflammatory
- gold nanoparticles
- photodynamic therapy
- living cells
- visible light
- metal organic framework