Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.
Vivek ThakareVu-Long TranMarco NatuzziEloïse ThomasMathieu MoreauAnthony RomieuBertrand CollinAlan CourteauJean-Marc VrigneaudCédric LouisStéphane RouxFrédéric BoschettiOlivier TillementFrançois LuxFranck DenatPublished in: RSC advances (2019)
A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64 Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.
Keyphrases
- high resolution
- computed tomography
- positron emission tomography
- magnetic resonance imaging
- fluorescence imaging
- photodynamic therapy
- contrast enhanced
- pain management
- metabolic syndrome
- adipose tissue
- drug delivery
- diffusion weighted imaging
- drug release
- walled carbon nanotubes
- tandem mass spectrometry
- single molecule
- metal organic framework