Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia/reperfusion injury via TLR4/Nox4 pathway in rats.

Jun Jian Dan Wang Yufeng Xiong Jingsong Wang Qingyuan Zheng Zhengyu Jiang Jiacheng Zhong Song Yang Lei Wang

Published in: Acta cirurgica brasileira (2023)

Our results suggested that puerarin inhibited oxidative stress and ferroptosis induced by I/R and, thus, delayed the progression of renal fibrosis, providing a new target for the treatment of renal fibrosis.

Keyphrases

oxidative stress
ischemia reperfusion injury
cell death
dna damage
induced apoptosis
immune response
signaling pathway
smoking cessation