Comparison of Standard-Dose Versus High-Dose Dexmedetomidine in Extracorporeal Membrane Oxygenation.
Erika L ZarfossJeffrey GaravagliaJ W Awori HayangaGalen M KabulskiPublished in: The Annals of pharmacotherapy (2022)
This represents the first evaluation of use of high-dose dexmedetomidine in ECMO. Rates of dexmedetomidine higher than 1.5 µg/kg/h were commonly used in patients on ECMO, with similar rates of adverse effects and need for concomitant propofol and analgesic agents. While high-dose dexmedetomidine may be as safe as standard dose, no additional efficacy was found.
Keyphrases
- high dose
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- low dose
- stem cell transplantation
- cardiac surgery
- respiratory failure
- end stage renal disease
- ejection fraction
- mechanical ventilation
- newly diagnosed
- chronic kidney disease
- acute kidney injury
- intensive care unit
- patient reported outcomes