Primary malignant melanoma of cervix and vagina.
Jae Hoon LeeJisun YunJung-Won SeoGo-Eun BaeJeong-Won LeeSang-Wun KimPublished in: Obstetrics & gynecology science (2016)
Primary malignant melanoma (MM) accounts for 1% of all cancers, and only 3% to 7% of these tumors occur in the female genital tract. Data are limited with respect to the basis for treatment recommendations because of the rarity of MM. The overall prognosis of melanomas of the female genital tract is very poor. Two cases of MM of the female genital tract are presented. The first case is of a 70-year-old female patient who complained of left thigh pain and underwent magnetic resonance imaging that showed cervical cancer with involvement of the vagina, bladder, and parametrium, in addition to multiple bony metastases of the proximal femur, acetabulum, and both iliac bones. The second case is of a 35-year-old female patient who suffered from vaginal bleeding for 5 months, and she was diagnosed as having primary vaginal melanoma. The patient underwent radical surgery and two additional surgeries because of recurrence of cancer in both inguinal areas. After surgery, the patient received adjuvant immunotherapy, radiation therapy, and chemotherapy. In both the aforementioned cases, the pathologic diagnosis was made after immunohistochemical analysis, i.e., the tumor cells were stained with HMB-45 and S100, and were found to be positive for both immunostains.
Keyphrases
- case report
- radiation therapy
- magnetic resonance imaging
- minimally invasive
- prostate cancer
- chronic pain
- locally advanced
- computed tomography
- squamous cell carcinoma
- atrial fibrillation
- machine learning
- spinal cord injury
- electronic health record
- spinal cord
- neuropathic pain
- neoadjuvant chemotherapy
- body composition
- rectal cancer
- clinical practice
- deep learning
- percutaneous coronary intervention
- soft tissue
- free survival
- big data