African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.

Manjunath Siddappa Shahid Hussain Sajad A Wani Jason A White Hancong Tang Jaimie S Gray Hedieh Jafari Hsu-Chang Wu Mark D Long Isra Elhussin Balasubramanyanam Karanam Honghe Wang Rebecca Morgan Gary Hardiman Isaacson B Adelani Solomon Oladapo Rotimi Bernice Ofori Larisa Nonn Melissa B Davis Rick A Kittles Chanita Hughes Halbert Lara E Sucheston-Campbell Clayton C Yates Moray J Campbell

Published in: Cancer research communications (2023)

Our study identified that genomic ancestry drives the VDR complex composition, genomic distribution, and transcriptional function, and is disrupted by BAZ1A and illustrates a novel driver for AA prostate cancer.

Keyphrases

prostate cancer
african american
radical prostatectomy

gene expression
copy number

single cell
transcription factor

genome wide
dna methylation