Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents.
Jaime Sou Da Rosa DuqueSamuel M S ChengCarolyn A CohenDaniel LeungXiwei WangXiaofeng MuYuet ChungTsun Ming LauManni WangWenyue ZhangYanmei ZhangHoward H W WongLeo C H TsangSara ChaothaiTsz Chun KwanJohn K C LiKarl C K ChanLeo L H LukJenson C H HoWing Yan LiAmos M T LeeJennifer H Y LamSau Man ChanWilfred H S WongIssan Y S TamMasashi MoriSophie A ValkenburgMalik PeirisWenwei TuYu Lung LauPublished in: World journal of pediatrics : WJP (2023)
This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARS-CoV-2 vaccination and serves as the basis for future research to improve the immunogenicity of inactivated vaccines.