Arenarialins A-F, Anti-inflammatory Meroterpenoids with Rearranged Skeletons from the Marine Sponge Dysidea arenaria .
Jia-Xin LiRu-Yi ShangDong-Dong XieXiang-Chao LuoTian-Yong HuBao-Hui ChengHou-Wen LinHou-Wen LinPublished in: Journal of natural products (2024)
Six new sesquiterpene quinone/hydroquinone meroterpenoids, arenarialins A-F ( 1 - 6 ), were isolated from the marine sponge Dysidea arenaria collected from the South China Sea. Their chemical structures and absolute configurations were determined by HRMS and NMR data analyses coupled with DP4+ and ECD calculations. Arenarialin A ( 1 ) features an unprecedented tetracyclic 6/6/5/6 carbon skeleton, whereas arenarialins B-D ( 2 - 4 ) possess two rare secomeroterpene scaffolds. Arenarialins A-F showed inhibitory activity on the production of inflammatory cytokines TNF-α and IL-6 in LPS-induced RAW264.7 macrophages with arenarialin D regulating the NF-κB/MAPK signaling pathway.
Keyphrases
- lps induced
- signaling pathway
- inflammatory response
- pi k akt
- anti inflammatory
- high resolution
- magnetic resonance
- rheumatoid arthritis
- density functional theory
- epithelial mesenchymal transition
- induced apoptosis
- electronic health record
- molecular dynamics
- molecular dynamics simulations
- oxidative stress
- big data
- tissue engineering
- solid state
- high resolution mass spectrometry
- cell proliferation
- machine learning
- data analysis
- mass spectrometry
- deep learning
- liquid chromatography