Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction.

These tracing studies identify limitations in AAV2retro-mediated retrograde transduction of a subset of projection neurons, specifically those that express NA and project to the spinal cord. This is likely to have implications for the study of NA-containing projections as well as other types of projection neuron in the central nervous system.