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A pilot study of radiation-induced bystander effect in radio-adapting frogs at a radiologically contaminated site located on the chalk river laboratories property.

Nguyen T K VoHarleen SinghMarilyne StuartColin B SeymourCarmel E Mothersill
Published in: International journal of radiation biology (2021)
The clonogenic RIBE reporter assay using HPV-G and calcium flux measurements are useful diagnostic tools for RIBE assessment of field biological samples, specifically those from frogs. RAR induced by environmentally relevant low-dose radiation induces protective bystander response. Bcl-2 and c-myc are reliable biomarkers for evaluating low dose radiation responses in wild populations of amphibians. Overall, this pilot study emphasizes the importance of looking at non-targeted effects (NTEs) in natural populations of non-human biota that could be vulnerable to chronic low-dose radiation exposures.
Keyphrases
  • low dose
  • radiation induced
  • high dose
  • radiation therapy
  • endothelial cells
  • genetic diversity
  • heavy metals
  • air pollution
  • high throughput
  • drinking water
  • crispr cas
  • high grade
  • cancer therapy
  • single cell