Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes.

Olivier MalaiseGeneviève PaulissenCéline DeroyerFederica CiregiaChristophe PouletSophie NeuvilleZelda PlenerChristophe DanielPhilippe GilletChantal LechanteurJean-Marc BrondelloDominique de SenyMichel Malaise

Published in: Journal of clinical medicine (2021)

We provide reassuring in vitro data about the use of GC regarding cellular senescence involvement in OA: the GC prednisolone did not induce a senescent phenotype in OA FLS (the proliferation ratio was even higher) and in MSC and did not worsen cellular senescence establishment.

Keyphrases

dna damage
endothelial cells
stress induced
signaling pathway
electronic health record
big data
machine learning
high resolution
wound healing
liquid chromatography