Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes.
Olivier MalaiseGeneviève PaulissenCéline DeroyerFederica CiregiaChristophe PouletSophie NeuvilleZelda PlenerChristophe DanielPhilippe GilletChantal LechanteurJean-Marc BrondelloDominique de SenyMichel MalaisePublished in: Journal of clinical medicine (2021)
We provide reassuring in vitro data about the use of GC regarding cellular senescence involvement in OA: the GC prednisolone did not induce a senescent phenotype in OA FLS (the proliferation ratio was even higher) and in MSC and did not worsen cellular senescence establishment.