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Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes.

Olivier MalaiseGeneviève PaulissenCéline DeroyerFederica CiregiaChristophe PouletSophie NeuvilleZelda PlenerChristophe DanielPhilippe GilletChantal LechanteurJean-Marc BrondelloDominique de SenyMichel Malaise
Published in: Journal of clinical medicine (2021)
We provide reassuring in vitro data about the use of GC regarding cellular senescence involvement in OA: the GC prednisolone did not induce a senescent phenotype in OA FLS (the proliferation ratio was even higher) and in MSC and did not worsen cellular senescence establishment.
Keyphrases
  • dna damage
  • endothelial cells
  • stress induced
  • signaling pathway
  • electronic health record
  • big data
  • machine learning
  • high resolution
  • wound healing
  • liquid chromatography