Inhibition of Importin- α -Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis.
Maulana A EmpituMitsuhiro KikyoNaritoshi ShirataHiroyuki YamadaShin-Ichi MakinoIka N KadariswantiningsihMasashi AizawaJaakko PatrakkaKatsuhiko NishimoriKatsuhiko AsanumaPublished in: Journal of the American Society of Nephrology : JASN (2023)
Nuclear translocation of dendrin promotes cell detachment-induced apoptosis in podocytes. Therefore, inhibiting importin- α -mediated dendrin nuclear translocation is a potential strategy to prevent podocyte loss and glomerulosclerosis.