The Prognostic Impact of NK/NKT Cell Density in Periampullary Adenocarcinoma Differs by Morphological Type and Adjuvant Treatment.

Sebastian LundgrenCarl Fredrik WarfvingeJacob ElebroMargareta HebyBjörn NodinAgnieszka KrzyzanowskaAnders BjartellKarin LeanderssonJakob EberhardKarin Jirström

Published in: PloS one (2016)

This study demonstrates that abundant infiltration of CD56+ NK/NKT cells is associated with a prolonged survival in periampullary adenocarcinoma. However, the negative interaction with adjuvant treatment is noteworthy. NK cell enhancing strategies may prove to be successful in the management of these cancers.

Keyphrases

nk cells
early stage
squamous cell carcinoma
induced apoptosis
stem cells
oxidative stress
signaling pathway
rectal cancer