Tumour-associated macrophages and Schwann cells promote perineural invasion via paracrine loop in pancreatic ductal adenocarcinoma.

Bin ZhangXiaofeng GuoLeyi HuangYuting ZhangZhiguo LiDan SuLongfa LinPeng ZhouHuilin Ye Yanan Lu Quanbo Zhou

Published in: British journal of cancer (2023)

Our study demonstrates that the bFGF/IL-33 positive feedback loop between Schwann cells and TAMs is essential in the process of PNI of PDAC. The bFGF/PI3K/Akt/c-myc/GFAP pathway would open potential avenues for targeted therapy of PDAC.

Keyphrases

cell cycle arrest
pi k akt
induced apoptosis
signaling pathway
cell death
cell proliferation
transcription factor
minimally invasive
risk assessment