Login / Signup

Genomic variation in weedy and cultivated broomcorn millet accessions uncovers the genetic architecture of agronomic traits.

Qiong LuHainan ZhaoZhengquan ZhangYuhe BaiHaiming ZhaoGuoqing LiuMinxuan LiuYunxiao ZhengHaiyue ZhaoHuihui GongLingwei ChenXizhen DengXiangde HongTianxiang LiuBaichuan LiPing LuFeng WenLun WangZhijiang LiHai LiHaiquan LiLike ZhangWenhui MaChunqing LiuYan BaiBeibei XinJian ChenLizhu EJinsheng LaiWeibin Song
Published in: Nature genetics (2024)
Large-scale genomic variations are fundamental resources for crop genetics and breeding. Here we sequenced 1,904 genomes of broomcorn millet to an average of 40× sequencing depth and constructed a comprehensive variation map of weedy and cultivated accessions. Being one of the oldest cultivated crops, broomcorn millet has extremely low nucleotide diversity and remarkably rapid decay of linkage disequilibrium. Genome-wide association studies identified 186 loci for 12 agronomic traits. Many causative candidate genes, such as PmGW8 for grain size and PmLG1 for panicle shape, showed strong selection signatures during domestication. Weedy accessions contained many beneficial variations for the grain traits that are largely lost in cultivated accessions. Weedy and cultivated broomcorn millet have adopted different loci controlling flowering time for regional adaptation in parallel. Our study uncovers the unique population genomic features of broomcorn millet and provides an agronomically important resource for cereal crops.
Keyphrases
  • genome wide
  • copy number
  • genome wide association
  • dna methylation
  • climate change
  • wastewater treatment
  • single cell
  • antiretroviral therapy
  • sensitive detection
  • loop mediated isothermal amplification
  • hiv testing