Poor effect of osimertinib on EGFR exon 20 insertion-positive lung adenocarcinoma: A case report.
Yuji InagakiAkihiro TamiyaYoshinobu MatsudaKouji AzumaYuichi AdachiTakatoshi EnomotoShunichi KounoYoshihiko TaniguchiNobuhiko SaijoKyoichi OkishioShinji AtagiPublished in: Medicine (2020)
EGFR exon 20 insertion mutations must be classified in more detail to assess the efficacy of EGFR tyrosine kinase inhibitors. Osimertinib doses that provide favorable therapeutic windows should be considered. Further clinical research is required to clarify the efficacy of osimertinib and other drugs for exon 20 insertion mutations.