Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages.

Kuo-Feng HuaYu-Bei LinHsiao-Wen ChiuWei-Ting WongShuk-Man KaChun-Hsien WuWen-Yu LinChien-Chun WangChung-Hua HsuHsien-Ta HsuChen-Lung HoLan-Hui Li

Published in: Journal of inflammation (London, England) (2024)

CA shows promise as a nutraceutical for mitigating S. sonnei infection by diminishing inflammation and enhancing phagocytosis and the bactericidal activity of macrophages against S. sonnei.

Keyphrases

nlrp inflammasome
oxidative stress
cell death
signaling pathway
endoplasmic reticulum stress
big data
machine learning
protein kinase
deep learning