Clival paragangliomas: a report of two cases involving the midline skull base and review of the literature.
Jacob RuzevickEun Kyung KohLuis F Gonzalez-CuyarPatrick J CiminoKristen MoeLorena A WrightRichard FailorManuel FerreiraPublished in: Journal of neuro-oncology (2017)
Head and neck paragangliomas are rare neuroendocrine tumors that arise from paraganglion cells of the parasympathetic nervous system. Paragangliomas arising from the midline skull base have only rarely been reported. Surgery is the mainstay of treatment and adjuvant radiation is often recommended. These tumors can rarely secrete metanephrines and normetanephrines which can complicate operative management. Here we present two cases of clival paragangliomas with unique clinical presentations and review the previous literature on skull base paragangliomas.
Keyphrases
- neuroendocrine tumors
- induced apoptosis
- systematic review
- minimally invasive
- early stage
- cell cycle arrest
- coronary artery bypass
- heart rate variability
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- coronary artery disease
- blood pressure
- cell proliferation
- percutaneous coronary intervention
- smoking cessation
- pi k akt
- replacement therapy