Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunity.
Leanne P M van LeeuwenMarloes GrobbenCorine H GeurtsvanKesselPauline M EllerbroekGodelieve J de BreeJudith PotjewijdAbraham RutgersHetty JolinkFrank L van de VeerdonkMarit J van GilsRory D de VriesVirgil A S H Dalmnull nullPublished in: Journal of clinical immunology (2023)
A similar decline in IgG titers and T cell responses was observed in patients with IEI when compared to healthy controls 6 months after mRNA-1273 COVID-19 vaccination. The limited beneficial benefit of a third mRNA COVID-19 vaccine in previous non-responder CVID patients implicates that other protective strategies are needed for these vulnerable patients.