Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference.

Yuri A BlednovAdriana J Da CostaTamara TarboxOlga PonomarevaRobert O Messing Robert Adron Harris

Published in: Alcoholism, clinical and experimental research (2018)

Apremilast produced stable reductions in voluntary EtOH consumption and was rapidly distributed to plasma and tissues (including the brain), suggesting that it may be an improved PDE4 inhibitor for medication development and repurposing efforts to treat alcohol abuse.

Keyphrases

gene expression
healthcare
white matter
resting state
high fat diet induced
quality improvement
alcohol consumption
adverse drug
multiple sclerosis
skeletal muscle
insulin resistance