The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease.
Bianca A TrombettaBecky C CarlyleAaron M KoenigLeslie M ShawJohn Q TrojanowskiDavid A WolkJoseph J LocascioSteven E ArnoldPublished in: PloS one (2018)
Assays for these CSF analytes demonstrate consistent sensitivity, reliability, and biotemporally stability for use in a multiple pathophysiological CSF biomarker panel to profile AD. Their qualification enables further investigation for use in AD diagnosis, staging and progression, disease mechanism profiling, and clinical trials.