Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent "NoGlow" Mice.

Timothy N Trotter Andrea Wilson Jason McBane Carina E Dagotto Xiao-Yi Yang Jun-Ping Wei Gangjun Lei Hannah L Thrash Joshua C Snyder Herbert Kim Lyerly Zachary Conrad Hartman

Published in: Cancer research communications (2024)

Multitolerant NoGlow mice enable tracking and gene manipulation of transplanted tumor cells without immune-mediated rejection, thus providing a platform to investigate novel mechanisms of adaptive immunity related to metastasis, immunotherapy, and tolerance.

Keyphrases

high fat diet induced
genome wide
insulin resistance
gene expression
adipose tissue
dna methylation
skeletal muscle