Mechanochemical Iridium(III)-Catalyzed B-Amidation of o-Carboranes with Dioxazolones.

Mechanochemistry was successfully applied to the functionalization of carboranes. The mechanochemical iridium(III)-catalyzed regioselective B(3)- and B(4)-amidation of unsubstituted o-carboranes with dioxazolones was developed. In addition, the mechanochemical iridium(III)-catalyzed regioselective B(4)-amidation of substituted o-carboranes was demonstrated. Because mechanochemical B-amidation proceeds smoothly without organic solvents or external heating, the present method is regarded as a sustainable and environmentally friendly surrogate for typical solvent-based reactions.