Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth.

Yizheng ZhangChuchu ZhangJiehan LiMeimei JiangShuning GuoGe YangLingling ZhangFeng WangShiqi YiJiangang WangYang FuYingjie Zhang

Published in: Cell communication and signaling : CCS (2022)

Our findings demonstrated that AKT inhibition induced p53-SIRT6-PARP1 complex formation and the activation of parthanatos, which can be recognized as a novel potential therapeutic strategy for cancer. Video Abstract.

Keyphrases

dna damage
signaling pathway
cell proliferation
dna repair
oxidative stress
papillary thyroid
ischemia reperfusion injury
diabetic rats
high glucose
drug induced
endothelial cells