Associations of metabolic heterogeneity of obesity with frailty progression: Results from two prospective cohorts.
Di HeYiwen QiuMengsha YanTianjing ZhouZongxue ChengJun LiQiong WuZuyun LiuYimin ZhuPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Metabolically unhealthy overweight/obesity and normal weight, but not metabolically healthy overweight/obesity, accelerated frailty progression as compared with metabolically healthy normal weight. Regardless of obesity status, transitions from healthy metabolic status to unhealthy metabolic status accelerated frailty progression as compared with stable metabolically healthy normal weight. Our findings highlight the important role of metabolic status in frailty progression and recommend the stratified management of obesity based on metabolic status.