Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system.
Dana M AlhattabIoannis IsaioglouSalwa AlshehriZainab N KhanHepi H SusaptoYanyan LiYara MarghaniArwa A AlghuneimRubén Díaz-RúaSherin AbdelrahmanShuroug Al-BihaniFarid AhmedRaed I FelimbanHeba AlkhatabiRaed AlserihiMalak AbedalthagafiAlShaibani AlFadelAbdalla AwidiAdeel Gulzar ChaudharyJasmeen MerzabanCharlotte A E HauserPublished in: Biomaterials research (2023)
Our results demonstrate the importance of developing 3D biomimicry models that closely recapitulate the in vivo conditions to gain deeper insights into drug resistance mechanisms and novel therapy development. These models can also improve personalized medicine by testing patient-specific treatments.